ZYMOX PLUS Advanced Otic Enzymatic Solution with 1% Hydrocortisone, Authentic Product Made in the USA


1.25 oz

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Contains a patented combination of enzymes to provide relief of persistent or recurring ear irritations and promote healthy ears. Advanced Formula ZYMOX Otic Plus 1% Hydrocortisone features increased potency of the patented LP3 Enzyme System to aid in removing ear exudate PLUS four additional biofilm-reducing enzymes formulated to destroy the hard-to-penetrate biofilm and the addition of 1% Hydrocortisone to reduce itching due to inflammation, dermatitis, and other minor skin irritations.  This advanced enzyme technology makes caring for your pet’s ears easy with reduced touching of sensitive ears.

This product contains 1% hydrocortisone and is not for use on pregnant or lactating females.

Made in the USA.


  • Resistant otitis
  • Antibacterial, antifungal, anti-yeast
  • Antibiofilm technology
  • Itch relief
  • Irritated or inflamed ears
  • Removal of ear exudate
  • Promotes healthy ears
  • For dogs and cats
  • For pets who swim
  • Pets who live in moist or hot environments


  • Soothing
  • Non-toxic
  • No PRE-CLEANING of the ear
  • Fear-free ear care
  • Easy, once daily application
  • No antibiotics

Available sizes:  1.25 oz

Managing Bacterial Resistance

Biofilm producing infections are 10 to 100x more resistant to the effects of antimicrobial agents

What is Biofilm?

Biofilm is an ill-defined mix of polysaccharides, nucleic acids and proteins encased in a slimy matrix created by microorganisms to house DNA. Biofilm is the believed to be a culprit for antibiotic resistance and the reason many otitis cases are persistent or recurring.  Due to incomplete killing of cells, bacteria can remain hidden in a complex biofilm even after the infection appears to be resolved, patiently waiting for ideal conditions to multiply and re-infect.

How Advanced Formula ZYMOX PLUS Otic Works

The Advanced Formula ZYMOX PLUS features the patented LP3 Enzyme System PLUS four additional enzymes.  The combination of mutanase, dextranase, cellulase, and betagluconase work to attack the complex biolfilm structure, prevent adhesion and metabolize its components.  When combined with the antimicrobial LP3 Enzyme System, the results are antibacterial and antifungal along with effective biofilm removal.

Mutanase can exhibit diverse action pattern but fundamentally degrades [beta symbol] ẞ-1, 3-glucan to glucose, making it water soluble.

Dextranase is an enzyme which catalyzes the endohydrolysis of 1,6-a-glucosidic linkages in dextran resulting in damage to the biofilm.

Cellulase is critical to an antibiofilm enzyme preparation, as cellulose is found in most biofilms. Cellulase has been shown to significantly reduce biofilm formation by the pathogen Pseudomonas aeruginosa.

Beta glucanase is another important antibiofilm component that provides powerful anticandidal biofilm activity by lysing the glucans that are common in candida biofilms and compose up to 60% of fungal cell walls. Beta-glucan secreted by candida cells within biofilms significantly increase the organism’s resistance to antifungals and enzymatic breakdown of the beta-glucan can make candida more susceptible to destruction.

Benzyl Alcohol, Beta-Glucanase, Cellulase, Dextranase, Dextrose, D-Mannose, Glucose Oxidase, Glycerin, Hydroxypropyl Cellulose, Lactoferrin, Lactoperoxidase, Lysozyme, Mutanase, Potassium Iodide, Propylene Glycol, Purified Water, Hydrocortisone.

  • Do not clean ear prior to or during use. Doing so will disrupt the enzyme system.
  • Do not use in pets with known or suspected ear drum rupture or with known or suspected sensitivity to corticosteroids such as pregnant or lactating females or exotics.
  • Do not use in conjunction with other topical ear products or ear cleaners. 
  • Do not allow water in or near ear during use.
  •  If condition persists or worsens, discontinue use.
  • Keep out of reach of children. 
  • Not for use in humans.
  • Store at room temperature.

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